CHENG-GUANG LIANG, Ph. D, Professor

Research Field: Developmental Biology and Cell Biology

Telephone: +86-471-3679862

Email: liangcg@imu.edu.cn

Address: State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, Inner Mongolia University, 24 Zhao Jun Road, Hohhot, Inner Mongolia 010070, P.R. China

Group Introduction: http://smkxxy.imu.edu.cn/info/1072/3692.htm

Cheng-Guang Liang got Ph.D. degree in the Institute of Zoology, Chinese Academic of Sciences. From 2006 to 2010, Dr Liang finished postdoctoral training in Stanford University and worked as Associate Scientist in Temple University in USA. As outstanding scholar and higher-level talents, Dr Liang enrolled in Inner Mongolia University in China in 2010 and worked in the College of Life Science. In 2011, Dr Liang was supported by the Program for New Century Excellent Talents sponsored by Ministry of Education of China.

 Research work in Dr Liang’s group focused on mammalian oocyte maturation and early embryo development, including chromosome aneuploidy related human infertility and disease, autocrine/ paracrine regulated embryo development, environmental influence on reproduction, embryo development disorder, preimplantation diagnosis as well was new approaches in assisted reproductive technology.

Some major findings have been published in Endocrinology, Journal of Proteome Research, Developmental Biology, Biology of Reproduction, Molecular Reproduction & Development, Microscopy & Microanalysis, Theriogenology, Cell Cycle, et al. Dr Liang was invited to write review for Molecular Endocrinology, J Down Syndr Chr Abnorm. He participated in composing book chapter for Nuclear Transfer in Mouse Oocytes and Embryos, Introduction of cloning technology andManipulating the Mouse Embry-A Laboratory Manual (Chinese Version).

Dr Liang is now a regular member of Society for the Study of Reproduction. He was also elected as member of Specialized Committee in Reproductive field in Chinese Physiology Society. Dr Liang was invited as reviewer to evaluate manuscripts for the journal of Biology of Reproduction, Human Reproduction, Molecular Reproduction & Development, Cell Death & Disease, Environmental Toxicology et al.

STUDY AND TRAINING EXPERIENCE

1996.09-2000.07, College of Life Sciences, Inner Mongolia University, B.S.

2000.09-2003.07, College of Life Sciences, Inner Mongolia University, M.S.

2003.09-2006.07, Institute of Zoology, Chinese Academy of Sciences (Beijing), Ph.D.

2006.08-2007.06, Division of Reproductive Biology, Stanford University, Post Doc Fellow

2007.06-2010.06, Fels Institute for Cancer Research and Molecular Biology, Temple University, Post Doc Fellow

WORK EXPERIENCE

2010.06-2010.08, Fels Institute for Cancer Research and Molecular Biology, Temple University, Associate Scientist.

2010.09-2011.07, College of Life Sciences, Inner Mongolia University, Teacher

2011.08-Now, College of Life Sciences, Inner Mongolia University, Professor

RESEARCH ACTIVITIES

➢  Molecular mechanism in oocyte meiotic maturation and early embryonic development

➢  Environmental influence on reproduction

➢  Developing new approaches in assisted reproductive technology

Grant as Principle Investigator

➢  National Basic Research Program of China

➢  The National Natural Science Foundation of China

➢  Program for New Century Excellent Talents in University

➢  Open Major Basic Research Projects in Inner Mongolia

➢  Outstanding youth fund in Inner Mongolia

➢  Key Project of Chinese Ministry of Education

➢  Specialized Research Fund for the Doctoral Program of Higher Education (20111501120006)

PUBLICATIONS

Papers can be found through the following link:

http://www.ncbi.nlm.nih.gov/pubmed/?term=cheng-guang+liang

1.       Xiang-Wei Kong, Dong-Hui Wang, Cheng-Jie Zhou, Hong-Xia Zhou, Cheng-Guang Liang^*  Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Molecular Reproduction & Development 2016 : 83(11):1027-1040

2.       Dong-Hui Wang^#, Hong-Xia Zhou^#(co-1st author), Shu-Jun Liu, Cheng-Jie Zhou, Xiang-Wei Kong, Zhe Han, Cheng-Guang Liang^*. Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development.Theriogenology. 2018: 113: 92–101

3.       Li YJ，Han Z, Ge L，Zhou CJ，Zhao YF，Wang DH，Ren J，Niu XX，Liang CG^*C-Phycocyanin Protects Against Low Fertility by Inhibiting Reactive Oxygen Species in Aging Mice. Oncotarget 2016 :7(14):17393

4.       Zhou CJ, Wang DH, Niu XX, Kong XW, Li YJ, Ren J, Zhou HX, Lu A, Zhao YF, Liang CG^* High survival of mouse oocytes using an optimized vitrification protocol. Scientific Reports 2016:19(6):19465

5.       Zhou CJ, Wu SN, Shen JP, Wang DH, Kong XW, Lu A, Li YJ, Zhou HX, Zhao YF, Liang CG* The beneficial effects of cumulus cells and oocyte-cumulus cell gap junctions depends on oocyte maturation and fertilization methods in mice. PeerJ 2016:4:e1761

6.       Zhou HX, Ma YZ, Liu YL, Chen Y, Zhou CJ, Wu SN, Shen JP, Liang CG^* Assessment of Mouse Germinal Vesicle Stage Oocyte Quality by Evaluating the Cumulus Layer, Zona Pellucida, and Perivitelline Space. PLoS ONE 2014:9(8): e105812

7.       Zhao J, Wang L, Zhou HX, Liu L, Lu A, Li GP, Schatten H, Liang CG^* Clathrin heavy chain 1 is required for spindle assembly and chromosome congression in mouse oocytes. Microscopy & Microanalysis 2013:19:1364

8.       Wang L, Lu A, Zhou HX, Sun R, Zhao J, Zhou CJ, Shen JP, Wu SN, Liang CG^* Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development. PLoS ONE 2013: 8(5): e63173

9.       Han ZM^#, Liang CG^#, Cheng Y^# (contribute equally), Duan X, Zhong Z, Potireddy S, Moncada C, Merali S, Latham KE^*. Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos. J. Proteome Res. 2010:9:6025

10.    Liang CG, Han Z, Cheng Y, Zhong Z, Latham KE^*. Effect of ooplasm transfer on paternal genome function in mice. Human Reproduction. 2009:24:2718

11.    Li M^#, Liang CG^# (co-1^stauthor), Xiong B, Xu BZ, Lin SL, Hou Y, Chen DY, Schatten H, Sun QY^*. PI3-Kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte. Domest Anim Endocrinol. 2007: 34:360

12.    Liang CG, Su YQ, Fan HY, Schatten H and Sun QY^*. Mechanisms regulating oocyte meiosis resumption: the role of mitogen-activated protein kinase. (Invited Review) Mol Endocrinol. 2007:21:2037

13.    Liang CG, Huo LJ, Zhong ZS, Chen DY, Schatten H, Sun QY^*. Cyclic adenosine 3',5'-monophosphate-dependent activation of mitogen-activated protein kinase in cumulus cells is essential for germinal vesicle breakdown of porcine cumulus-enclosed oocytes. Endocrinology. 2005:146:1444

14.    Liang CG, Sun QY ^* （Book Chapter）Manipulating the Mouse Embry-A Laboratory Manual (Chinese Version) 2005：411-434 ISBN:7-5025-7667-3

15.    Liang CG^* (Book) Introduction of cloning technology 2013，ISBN：978-7-5167-0808-8